Fig. 7
From: Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination
TET1 and TET2 differentially bind to osteogenic gene regions. BMSC were cultured under normal growth (Cont) or osteogenic (Osteo) conditions and then processed for chromatin extraction. Recruitment of TET molecules to genomic regions was assessed by chromatin immunoprecipitation and normalised to the genomic input control. a Relative enrichment of TET1 on RUNX2 transcription start site (TSS), exon, intron and 3′ untranslated region (UTR). b Relative enrichment of TET1 on BMP2 TSS, exon and intron regions. c Relative enrichment of TET2 on RUNX2 TSS, exon, intron and UTR. d Relative enrichment of TET2 on BMP2 TSS, exon and intron regions. Data represent mean S.E.M., n = 3 BMSC donors, *p ≤ 0.05, one-way ANOVA with multiple comparison analyses