Fig. 10
From: Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination
Function of TET1 and TET2 in human MSC lineage determination. a 5hmC mark on osteogenic genes is directly attributed to TET2 and to some extent TET1 allowing a permissive transcriptional state. TET1 also represses osteogenic gene transcription presumably by recruiting SIN3A and EZH2, where its removal during osteogenesis activates gene transcription. b TET2 is directly responsible for 5hmC on adipogenic genes, allowing for a permissive transcriptional state, where TET1 indirectly represses adipogenic gene transcription