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Fig. 7 | Epigenetics & Chromatin

Fig. 7

From: Automated in situ chromatin profiling efficiently resolves cell types and gene regulatory programs

Fig. 7

AutoCUT&RUN identifies cell-type-specific enhancer elements. a Scaled Venn diagram showing the overlap of accessible chromatin sites (ATAC-seq peaks) and peaks called on H3K4me2 AutoCUT&RUN profiles in H1 cells. Numbers are provided as 1 thousand peak units. b Mean enrichment of H3K4me1 (green) H3K4me2 (black) and H3K4me3 (blue) over all H3K4me2 +/ATAC + TSSs. c Mean enrichment of H3K4me1 (green) H3K4me2 (black) and H3K4me3 (blue) over all H3K4me2 +/ATAC + distal sites. d Hierarchically clustered matrix of Spearman correlations of enhancer chromatin scores in VUMC-10 (V) and SU-DIPG-XIII (S) cells grown in cell culture (C.C.) or as xenografts (Xeno.), as well as H1 and K562 cells. e Genome browser tracks showing the location of putative enhancer elements (arrow heads) that are specific to VUMC-10 cells (V), both DMG cell lines (D), or common to DMG cells and H1 cells (C) at a representative locus (SOX2). In VUMC-10 and SU-DIPG-XIII cells, the H3K27ac track that is shown was also profiled manually as a quality control (*)

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