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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation

Fig. 2

The expression of ex14D-Ezh2 in spermatocytes is responsible for the establishment of H3K27me2. ac The dynamics of H3K27me3 and H3K4me3 enrichment on E2f1-3 during spermatogenesis. Spermatocytes were isolated from postnatal day 12 (p12), 17 (p17), and 30 (p30) testes for ChIP-seq analysis. df RNA-seq analysis of E2f1-3 transcription in germ cells purified from p9 and p17 testes. The representative sample tracks for each time point are presented here. g Assessment of H3K27 methylation in different meiotic cell populations. Cryosections of 4-month-old testis were immunostained for indicated proteins. (l) leptotene spermatocytes; (z) zygonema; (p) pachynema; (d) diplonema. Scale bar: 20 μm

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