TY - JOUR AU - Skrypek, Nicolas AU - Bruneel, Kenneth AU - Vandewalle, Cindy AU - De Smedt, Eva AU - Soen, Bieke AU - Loret, Nele AU - Taminau, Joachim AU - Goossens, Steven AU - Vandamme, Niels AU - Berx, Geert PY - 2018 DA - 2018/11/16 TI - ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition JO - Epigenetics & Chromatin SP - 70 VL - 11 IS - 1 AB - Epithelial mesenchymal transition (EMT) is tightly regulated by a network of transcription factors (EMT-TFs). Among them is the nuclear factor ZEB2, a member of the zinc-finger E-box binding homeobox family. ZEB2 nuclear localization has been identified in several cancer types, and its overexpression is correlated with the malignant progression. ZEB2 transcriptionally represses epithelial genes, such as E-cadherin (CDH1), by directly binding to the promoter of the genes it regulates and activating mesenchymal genes by a mechanism in which there is no full agreement. Recent studies showed that EMT-TFs interact with epigenetic regulatory enzymes that alter the epigenome, thereby providing another level of control. The role of epigenetic regulation on ZEB2 function is not well understood. In this study, we aimed to characterize the epigenetic effect of ZEB2 repressive function on the regulation of a small Rab GTPase RAB25. SN - 1756-8935 UR - https://doi.org/10.1186/s13072-018-0239-4 DO - 10.1186/s13072-018-0239-4 ID - Skrypek2018 ER -