Fig. 6

Hypothetical model of three different genomic architectures underlying epigenetic regulations of BPs. BPs that drive single-cell expression patterns observed in the BLE state show large TSS distance and higher abundance of repression associated marks and depletion of most TFs. BSD and BWD, on the other hand, exhibit smaller TSS distance and more TF binding compared to BLE. In addition, the transcripts span of the H gene is observed to be significantly smaller compared to the L gene. BPs categorized in BND show the smallest TSS distance with the most TF binding events that require more accessible DNA to regulate both the L and H genes