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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Integrative analysis of single-cell expression data reveals distinct regulatory states in bidirectional promoters

Fig. 2

Single-cell RNA-seq expression in bidirectional promoters. a Hierarchical clustering of the HepG2 single-cell transcript expression matrix visualized as a heatmap (log2, TPM). The four distinct clusters (BLE, BSD, BWD, BND) are referred to as transcription state in this manuscript. b Number of BPs falling into each transcription state in HepG2 and K562 cells and their overlap. c Number of BPs falling into the gene product categories (NC → NC, NC → PC, etc.) in HepG2. Statistically enriched values are shown in bold (hypergeometric test p <= 0.05). d Ratio of concordant BPs shown separately in each state for both cell lines as well as their overlap. e Examples of concordant and discordant BPs in HepG2. f CAGE read counts, measured for each bidirectional gene (L and H), shown for each transcription state. Color code as in a. Significant differences are marked with * (paired and two-sided Mann–Whitney test, p <= 0.05)

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