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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot

Fig. 3

Identification of hotspot-enriched proteins during meiosis. Mass spectrometry was used to determine the abundance of proteins from affinity purifications of hotspot and basal control MiniCs at four time points of meiosis. a Heat map shows Pearson correlation coefficient (r) for each pairwise comparison of all experimental conditions and all biological replicates; r values range from 0.6 (darkest red) to 1.0 (white) (see Additional file 1: Fig. S4 for additional details). b Relative abundance (hotspot vs basal control) of every detected protein at each time point of meiosis; note log2 scale. c Density plots show changes in relative protein abundance (X-axis) versus sum of total protein abundance (Y-axis) over time. d Heat map shows log2 relative enrichment of proteins in hotspot versus basal control for a subset of the chromatin-associated/nuclear proteins that were enriched at one or more time points in the hotspot sample (for a more extensive list, see Additional file 1: Table S2)

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