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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Non-canonical Drosophila X chromosome dosage compensation and repressive topologically associated domains

Fig. 6

Repressive TAD genes that are less sensitive to msl or mof knockdown lack MOF enrichment at their gene bodies. Top four panels demonstrate normalized ChIP signals of MOF and H4K16Ac from S2 cells as well as male salivary glands. The bottom three panels display RNA-Seq read coverages from our re-analysis of Zhang et al. [23]. The plots are scaled based on their maximum coverage from one of the three samples: control RNAi, mof RNAi and msl-2 RNAi (indicated in the square brackets). Note that there is no sample-to-sample normalization because the total number of reads is similar across the three samples; 7.2, 7.5 and 8.1 million mapped reads for the control, mof RNAi and msl-2 RNAi samples, respectively. a An autosomal gene (RpL32). b, c Canonical MSL targets genes. CG9947 (B) and arm (c). de Repressive target genes that are compensated via the non-canonical dosage compensation. CG34430 (d), CG9521 (e), CG8675 (f) and CG2875 (g)

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