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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs

Fig. 4

Distribution of MZ twin correlations for individual methylation sites assessed by the EPIC array as a function of probe category, functional elements, and mQTLs. a Distribution of MZ twin correlations for methylation probes that are common to EPIC and HM450 (pink) and for methylation probes that are unique to the EPIC array (blue). bf Distribution of MZ twin correlations for methylation probes that overlap with (blue) or do not overlap with (pink) FANTOM4 enhancers (b), FANTOM 5 enhancers (c), Encode DHS (d), Encode open chromatin (e), Encode transcription factor binding sites (f). g Density of distances between methylation sites and the most strongly associated significant meQTL SNP. h MZ twin correlations as a function of mQTLs. The cumulative proportion of methylation sites (y-axis) at each MZ twin correlation (x-axis), for all genome-wide methylation sites (black), sites that are not significantly associated with an mQTL (blue) and sites that are associated with at least one significant mQTL (purple)

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