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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours

Fig. 5

Transcriptional profiles of DMR-overlapping differentially expressed genes and markers of neurogenesis and neural stem cells. a Differential expression of the DMR-overlapping differentially expressed genes. Bars represent the mean of the relative quantification levels relative to the GBM100 tumours (relative expression = 1). Statistical significance was determined by One-way ANOVA. Error bars show SEM (n = 3 per group; technical triplicates per sample). *, ** p values < 0.05 and 0.01, respectively. b Heatmap of markers of neurogenesis and neural stem cells from the RNA-Seq profiles. For the GBM50, GBM3 and GBM0.2 cohorts, the fold changes (log2) of read counts to the mean value of the GBM100 cohort were plotted. The colour scheme from blue, white to red represents the level of expression from twofold down-regulation to twofold up-regulation

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