Fig. 1

Replenishment of mtDNA copy number in the GBM⁵⁰, GBM³ and GBM^0.2 tumours. Fold change in mtDNA copy number for GBM⁵⁰, GBM³ and GBM^0.2 tumours relative to the GBM¹⁰⁰ tumours. GBM¹⁰⁰, GBM⁵⁰, GBM³ and GBM^0.2 tumours were harvested at 65 days, 61 days, 83 days and 90 days after inoculation, respectively. Statistical significance was determined using one-way ANOVA (n = 3 tumours per group; technical triplicates per sample). No significant differences were identified between the groups