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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2cBmp7 locus

Fig. 6

Directionality control of chromatin folding at the Tfap2cBmp7 locus. a In the normal wild-type configuration, the locus is partitioned into the two domains by the action of the TZ. This ability originates from the divergent configuration of the two CTCF arrays, which induces directional chromatin folding to the diverging orientations from the TZ. Note that the central region of ca. 50 kb of the TZ behaves isotropically in terms of chromatin folding, which provides the TZ with another feature than blocking of the contact domains. b The directional folding disappeared upon the deletion of the TZ, which resulted in a merge of chromatin domains. c The folding directionality of Tfap2c is greatly influenced by the CTCF binding in the vicinity, but little by those at the TZ. The inversion of Tfap2c together with the CTCF sites altered the directionality drastically

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