Fig. 3

Cell-type-specific TF binding and histone modification events versus cell-type-specific compartments. a Relation between cell-type-specific A/B partition and CTCF binding sites for six cell lines. For all pair-wise comparisons, CTCF BSs specific to cell 1 (cell 2) showed a significant preference to AB (BA) genomic regions over BA (AB) regions. All p values are highly significant (–log10, Chi-square test). b Relation between cell-type-specific TFBSs and A/B compartments in the comparison between GM12878 and K562. For each of the 49 TFs we calculated the AB occupancy enrichment ratio as a measure for the preference of its cell-type-specific binding events to AB genomic regions over BA regions. Experiments are sorted by p value, and enrichment ratios are represented by bars. Red line: p value = 0.01 (statistically significant and nonsignificant results are presented by black and gray bars, respectively). c The same as B, but for histone modifications. The compared cell lines (using the first two letters of their names; e.g., GM = GM12878; K5 = K562) and the examined histone modification are indicated below each bar. The results for the repressive histone marks H3K27me3 and H3K9me3 are colored in red