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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Loss of SETDB1 decompacts the inactive X chromosome in part through reactivation of an enhancer in the IL1RAPL1 gene

Fig. 4

H3K4me2 gain within the 3′ end of the IL1RAPL1 gene on Xi in SETDB1 mutants. Human X ideogram with Xp21.3-p21.1 boxed and expanded below. White arrows correspond to genes. Beneath is ChIP-Seq profiles for RPE1 and S40 to H3K4me2, H3K9me3 and H3K27Ac (peak heights of 150, 25 and 100, respectively, covering chromosome X: 28,418,150-33,476,294 bp, hg19). The bottom panel is an expansion of the IL1RAPL1 gene locus (chromosome X: 28,605,681-29,974,017 bp, hg19), showing the same ChIP-Seq profiles (peak heights of 70, 12 and 90 respectively). The y-axis on the genome browser image is normalized read density. Colored translucent bands corresponding to the first half of the ChIP-Seq normalized read density have been added to assist in visualizing change regions. The location of IL1RAPL1 exons is indicated by vertical lines. The black horizontal line at bottom right corresponds to the region of most obvious chromatin profile change. The White horizontal scale bars correspond to 5 μm

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