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Fig. 9 | Epigenetics & Chromatin

Fig. 9

From: JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling

Fig. 9

Schematic model for Wnt modulation by JARID2 in a PRC2 complex-dependent manner. JARID2 directs the PRC2 complex to repress Sfrp1, a secreted negative regulator of Wnt. Repression of Sfrp1 allows Wnt-activated β-catenin to activate Myod1, which is required for myogenesis. Dashed arrowheads and T-bars represent the events following depletion of JARID2 (represented by fading oval)

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