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Table 2 Top 10 Braak stage DMCGs plus 25 selected CpGs from 200 top entries

From: DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

Rank P value (meta-analysis) P value (neuron) P value (glia) TargetID Chr Position Gene Region Probe SNPs FDR
1 1.50E−13 1.15E−06 3.83E−09 cg06549928 1 89990868 LRRC8B 5UTR   7.17624E−08
2 6.43E−11 4.64E−06 4.98E−07 cg21913630 7 128828599 SMO TSS200   1.53811E−05
3 2.05E−10 3.04E−05 2.54E−07 cg16562251 1 166845621 TADA1 1stExon   3.26918E−05
4 2.90E−10 1.15E−05 9.63E−07 cg08738571 12 32655192 FGD4 1stExon rs56168193 3.45416E−05
5 3.61E−10 9.00E−06 1.54E−06 cg22140756 2 177895827     3.45416E−05
6 4.81E−10 7.42E−06 2.52E−06 cg04913265 11 133939627 JAM3 Body   3.8353E−05
7 8.78E−10 1.69E−05 2.07E−06 cg20693608 4 113152836 AP1AR TSS200   6.0007E−05
8 1.57E−09 7.82E−06 8.20E−06 cg24449302 15 66679100 MAP2K1 TSS200 rs77540803 7.02674E−05
9 1.60E−09 7.69E−06 8.51E−06 cg13172549 7 27153636 HOXA3 5UTR   7.02674E−05
10 1.61E−09 2.63E−06 2.50E−05 cg04547723 14 75421960 PGF 5UTR   7.02674E−05
11 1.67E−09 1.49E−05 4.58E−06 cg07835289 1 236030215 LYST 5UTR   7.02674E−05
15 2.27E−09 0.00021772 4.33E−07 cg11817993 14 92572978 ATXN3 TSS200   7.02674E−05
21 5.19E−09 3.14E−05 7.12E−06 cg02037503 14 23540729 ACIN1 1stExon   0.000118237
27 1.04E−08 7.43E−05 6.24E−06 cg03040740 13 99084682 FARP1 Body rs6491426 0.000184279
32 1.44E−08 0.00087784 7.40E−07 cg13859639 11 2846716 KCNQ1 Body   0.000215287
38 2.41E−08 0.00041341 2.70E−06 cg03907612 6 41703314 TFEB 5UTR   0.000303416
39 2.60E−08 7.11E−05 1.70E−05 cg16568373 17 4853368 ENO3 TSS1500   0.000318944
48 3.48E−08 2.84E−05 5.76E−05 cg05884192 14 52515736 NID2 Body rs2516585 0.000334891
53 3.75E−08 0.00012506 1.42E−05 cg08883485 1 201619787 NAV1 Body   0.000334891
58 4.55E−08 4.14E−05 5.24E−05 cg23712970 14 23540735 ACIN1 1stExon   0.000374624
74 6.71E−08 1.05E−05 0.0003106 cg08843538 2 210288784 MAP2 1stExon   0.000429299
76 6.94E−08 4.79E−05 7.07E−05 cg04542489 14 23775746 BCL2L2 TSS1500   0.00043306
102 1.24E−07 4.82E−05 0.00012891 cg06355720 1 153333350 S100A9 3UTR rs743566 0.000581604
103 1.27E−07 5.37E−05 0.00011905 cg26327118 6 39693366 KIF6 TSS200   0.000589892
104 1.31E−07 1.08E−05 0.00061189 cg16258854 2 20648194 RHOB 1stExon rs1062292 0.000595763
111 1.41E−07 0.00052315 1.36E−05 cg08866780 21 27543523 APP TSS1500   0.000604315
112 1.42E−07 0.01466411 4.90E−07 cg03613822 17 7115140 DLG4 Body   0.000604315
126 1.71E−07 5.41E−06 0.00161641 cg06291595 14 74960292 NPC2 TSS1500   0.000646609
131 1.86E−07 0.01071281 8.90E−07 cg04153489 8 41655983 ANK1 TSS1500   0.000679278
133 1.99E−07 2.07E−05 0.00049571 cg19447671 2 176032513 ATF2 5UTR   0.000715825
134 2.04E−07 0.00058734 1.79E−05 cg10313337 16 68823690 CDH1 Body   0.000728335
141 2.18E−07 0.00020684 5.47E−05 cg01015899 12 120663812 PXN 5UTR   0.000737839
152 2.41E−07 2.45E−05 0.00051347 cg27212541 3 49507385 DAG1 TSS200   0.00075801
161 2.68E−07 0.00027187 5.17E−05 cg07745886 8 42150794 IKBKB Body   0.000796369
199 4.19E−07 0.00095868 2.35E−05 cg01231165 2 9695142 ADAM17 Body   0.001001966