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Table 1 Top 25 aging-DMCGs identified in the meta-analysis

From: DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

Rank P value (meta-analysis) P value (neuron) P value (glia) TargetID Chr Position Gene Region FDR
1 4.34E−27 6.58E−09 1.00E−20 cg13327545 10 22623548    2.0763E−21
2 9.38E−26 5.55E−10 2.69E−18 cg16867657 6 11044877 ELOVL2 TSS1500 2.2438E−20
3 2.53E−25 8.99E−09 4.56E−19 cg20224218 9 129261375 FAM125B Body 4.0346E−20
4 4.38E−25 5.03E−06 1.42E−21 cg10804656 10 22623460    5.2387E−20
5 6.46E−25 9.09E−14 1.17E−13 cg14919554 5 43018629    6.1811E−20
6 8.12E−25 2.95E−17 4.54E−10 cg02426178 19 10747142 SLC44A2 Body 6.4746E−20
7 1.65E−24 5.49E−16 5.01E−11 cg03984866 4 8161776 ABLIM2 TSS1500 1.0465E−19
8 1.75E−24 1.52E−09 1.92E−17 cg10906284 12 63544430 AVPR1A 1stExon 1.0465E−19
9 2.38E−24 2.13E−06 1.88E−20 cg17117277 19 3822126 ZFR2 Body 1.2651E−19
10 5.41E−24 2.75E−08 3.36E−18 cg06022942 10 8095484 FLJ45983 TSS200 2.5882E−19
11 7.95E−24 3.53E−14 3.86E−12 ch.6.1693624F 6 83767401 UBE2CBP Body 3.4576E−19
12 1.32E−23 5.62E−09 4.06E−17 cg24954207 3 128217091    5.2626E−19
13 1.77E−23 4.00E−09 7.68E−17 cg08234504 5 139013317    6.5138E−19
14 1.92E−23 8.17E−11 4.10E−15 cg02492920 7 150659969 KCNH2 Body 6.5384E−19
15 2.05E−23 1.01E−11 3.53E−14 cg14299508 8 105907690    6.5384E−19
16 3.75E−23 2.50E−12 2.64E−13 cg08594681 8 27468684 CLU 1stExon 1.1213E−18
17 4.63E−23 6.45E−14 1.27E−11 cg08342886 6 33240066 VPS52 TSS1500 1.303E−18
18 1.20E−22 9.22E−10 2.34E−15 cg00303378 1 159825552 VSIG8 Body 3.0971E−18
19 1.23E−22 1.21E−10 1.83E−14 cg23813012 1 14026482 PRDM2 TSS1500 3.0971E−18
20 1.38E−22 5.01E−10 4.98E−15 ch.13.22912778R 13 24014778    3.2806E−18
21 1.44E−22 1.20E−08 2.17E−16 cg06639320 2 106015739 FHL2 TSS200 3.2806E−18
22 1.77E−22 1.31E−09 2.45E−15 cg15393490 1 207996459    3.8491E−18
23 1.90E−22 6.33E−08 5.46E−17 cg26880525 1 209877941 HSD11B1 5UTR 3.8672E−18
24 1.94E−22 6.83E−13 5.17E−12 cg04211309 16 58056296    3.8672E−18
25 2.33E−22 5.12E−15 8.29E−10 cg09131339 1 109914235 SORT1 Body 4.4588E−18