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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species

Fig. 2

DNA methylation in gene features by expression deciles in muscle and in testis. Violin plots of DNA methylation in promoter (muscle, n = 2745; testis, n = 3345), first exon (muscle, n = 3537; testis, n = 4064), first intron (muscle, n = 2801; testis, n = 3122), rest of exons (muscle, n = 5523; testis, n = 6398) and rest of introns (muscle, n = 4043; testis, n = 4897) divided into deciles based on increasing ranking of gene expression measured as log2-transformed count per million (cpm) values. Box plots with rotated kernel density plots at both sides indicate the interquartile range, and white central dots the median of the distribution. Correlations between DNA methylation and gene expression were measured using Spearman’s rank correlation coefficient (ρ), and the significance levels are reported as follows: *p < 0.05; ***p < 0.001

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