Fig. 5
From: KDM1A microenvironment, its oncogenic potential, and therapeutic significance
Role of KDM1A in epithelial–mesenchymal transition. SNAI1 recruits the KDM1A corepressor complex, leading to the demethylation of H3K4me2 in the histone tails of E-cadherin-associated promoters. This demethylation ultimately inactivates these E-cadherin associated promoters. This SNAI1-mediated interaction of KDM1A with E-cadherin controls the processes of neural development and tumorigenesis