Fig. 3
From: KDM1A microenvironment, its oncogenic potential, and therapeutic significance
KDM1A interacting partners and functional diversity. The microenvironment of KDM1A contains various protein complexes (e.g., CoREST, NuRD, and RCOR2), receptors (estrogen, androgen, and TLX), noncoding RNAs (HOTAIR, SRA and TERRAs), microRNAs (miR-137 and miR-329), nonhistone proteins (p53, E2F1, and DNMT1) and transcription factors (TLA and SNAIL). The interaction of KDM1A with these diverse factors allows the dynamic regulation of different biological processes through the suppression and the activation of target gene expression depending upon the type of its interacting partner, i.e., the interaction of KDM1A with miR-137 downregulate the expression of KDM1A and in turn led to the differentiation of cells by activating the associated genes while its association with CoREST results in downregulation/suppression of target genes