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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation

Fig. 5

MYC and MYC transcriptional program are downregulated by CBP30 in K562. MYC and MYC transcriptional program are downregulated by CBP30 in K562.a GSEA of changes in gene expression caused by CBP30, JQ1 and C646 treatments shows enrichment in genes that are upregulated after MYC overexpression (MSigDB gene set MYC_UP.V1_UP). b mRNA (upper panel) and protein levels (lower panel) of K562 cells treated with 2 µM CBP30, 10 µM C646 and 150 nM JQ1 for 48 h. c MYC mRNA levels at the indicated time points in K562 cells treated with 2 µM and 5 µM CBP30. d MYC mRNA levels at 2 h after treatment of K562 cells with the indicated concentrations of CBP30 e MYC protein levels at 2 h after treatment of K562 cells with the indicated concentrations of CBP30. f Cell cycle distribution of K562 cells treated with different CBP30 concentrations for 48 or 72 h

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