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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation

Fig. 4

EP300 binding sites are co-occupied with GATA1 in K562. a Motif search in 400-bp regions centered on the constituents of top EP300 regions (n = 16,369) and predicted transcription factor binding using MEME Chip. The distribution of each motif relative to the EP300 peak is also shown. b Heat map of the density of EP300, H3K27ac and GATA1 signals at 10 Kb centered EP300 top occupied constituents and ranked according to EP300 signal. c Density of GATA1 and H3K27ac around 2Kbs of top EP300 binding sites constituents. d Levels of GATA1 mRNA (upper panel) or protein (lower panel) at different time points after treatment of K562 with 2 or 5 µM CBP30. e GSEA analysis of K562 cells treated with 5 µM CBP30 for 48 h shows enrichment in a set of genes downregulated after GATA1 siRNA in K562 cells. f GATA1 mRNA levels in the indicated subtypes of CCLE lines

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