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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation

Fig. 3

Genes associated with SE and/or occupied by EP300 are downregulated by CBP30 in K562. a Ranking of H3K27ac signal at genomic intervals marked with H3K27ac identifies super-enhancers in K562. b Ranking of EP300 signal at genomic intervals occupied by EP300 identifies top EP300 regions. c Overlap of genes associated with SE and top EP300 levels d Metagene representation of the mean of EP300 signal in regular enhancers (RE) and super-enhancers (SE). Mean size of regular enhancers and super-enhancers is shown. A 5 kb flanking region surrounding each enhancer region is also shown. e Overlap of genes downregulated by the 200 nM JQ1, 5 µM CBP30 or 10 µM C646 for 48 h and associated with super-enhancers. P value for the enrichment of super-enhancer associated genes in downregulated genes for each treatment is shown. f Overlap of genes downregulated by the individual treatments and occupied by top levels of EP300. P values for the enrichment of EP300 occupied genes in downregulated genes for each treatment is shown. g mRNA levels according to RNA-seq of selected genes affected by the CBP30 treatment and that are associated with super-enhancers and are bound by top EP300 levels, after treatment of K562 with 200 nM JQ1, 5 µM CBP30 and 10 µM C646 for 48 h

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