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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation

Fig. 2

Transcriptional profiles of K562 cells treated with JQ1, CBP30 and C646. a Overlap of downregulated genes caused by the treatment of K562 with 200 nM JQ1, 5 µM CBP30 and 10 µM C646 for 48 h. b Gene ontology of commonly downregulated genes showing enrichment in the indicated categories. c Overlap of genes downregulated in K562 by CBP30 at 2 and 5 μM after 48 h of treatment. d Log2 of the fold change to DMSO caused by the indicated treatments on genes commonly downregulated by 5 µM and 2 µM CBP30. e Heat map on the left represents the fold change of all genes comparing the indicated treatments to DMSO. On the right, the fold change of top 400 genes changing expression is shown. Genes have been ranked according to fold change in cells treated with 5 µM CBP30

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