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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation

Fig. 1

K562 are sensitive to CREBBP/EP300 inhibition. a Concentration-dependent (Log2 μM) growth inhibition curves of K562 cells treated with JQ1, C646 and CBP30 for 7 days. b EP300 and CREBBP protein levels after knock down of CREBBP or EP300 or both in K562. c Growth curves of K562 knock down for CREBBP or EP300 or both. *p value < 0.05 d Growth competition assays with cells transduced with gRNAs targeting diverse domains of CREBBP, EP300 and BRD4 including 5′ coding region (5′), bromodomain (BD), non-conserved regions of bromodomain (ncBD) and conserved regions of bromodomain (cBD)

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