Fig.Ā 1
From: CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation
K562 are sensitive to CREBBP/EP300 inhibition. a Concentration-dependentĀ (Log2 Ī¼M) growth inhibition curves of K562 cells treated with JQ1, C646 and CBP30 for 7Ā days. b EP300 and CREBBP protein levels after knock down of CREBBP or EP300 or both in K562. c Growth curves of K562 knock down for CREBBP or EP300 or both.Ā *p valueā<ā0.05 d Growth competition assays with cells transduced with gRNAs targeting diverse domains of CREBBP, EP300 and BRD4 including 5ā² coding region (5ā²), bromodomain (BD), non-conserved regions of bromodomain (ncBD) and conserved regions of bromodomain (cBD)