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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten

Fig. 5

Coverage comparison between HiSeq 2500 and HiSeq X Ten. a Plot shows the fraction of genome covered at different depths for four samples sequenced together on one lane of the HiSeq 2500 versus when each of the samples is sequenced on a single lane of the HiSeq X Ten. The coverage plot for the HiSeq 2500 HO mode is the merged coverage obtained from multiplexing the four samples. b Plot shows the fraction of CpG sites covered at different depths when four clinical samples are sequenced together on one lane of the HiSeq 2500 versus when each of the samples is sequenced on a single lane of the HiSeq X Ten. c, d Box plot showing the coverage distribution across exons, intergenic regions, introns, promoter regions and repeat regions of the genome for a sample sequenced on one lane of HiSeq X Ten (c) and HiSeq 2500 (d)

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