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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten

Fig. 3

Integrating whole genome and whole genome bisulphite sequencing. a Bar plot depicting the coverage obtained when both genomic and its corresponding bisulphite library is sequenced on the same lane of the HiSeq X Ten, for four prostate cancer samples sequenced in duplicate (a, b). b A representative IGV plot showing a C to T SNP identified in both the WGS and WGBS data at approximately 13× coverage. c Bar plot indicating the percentage of SNPs from WGBS concordant in spike-in WGS at 13× and 26× coverage. d A representative Venn diagram for one prostate cancer sample, 2a showing the number of SNPs concordant and discordant at 13× and 26× coverage for both WGBS and spike-in WGS

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