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Table 1 Serum biochemical parameters in F1/C-, F2-, and F3-GDM male mice at 8 weeks

From: Intrauterine hyperglycemia exposure results in intergenerational inheritance via DNA methylation reprogramming on F1 PGCs

 

Control (n = 10)

F1/C-GDM (n = 9)

F2/H-GDM (n = 10)

F2/N-GDM (n = 6)

F3-GDM (n = 10)

Fasting glucose (mM)

4.57 ± 0.23

4.38 ± 0.24

4.78 ± 0.20

4.54 ± 0.02

4.61 ± 0.31

Fasting insulin (mIU/l)

22.05 ± 6.97

21.87 ± 4.50

27.81 ± 9.95##

73.12 ± 9.45***

19.10 ± 7.43

TC (mM)

2.47 ± 0.06

2.65 ± 0.11

2.48 ± 0.11

2.48 ± 0.09

2.29 ± 0.16

TG (mM)

1.33 ± 0.11

1.32 ± 0.17

1.83 ± 0.12*,#

1.20 ± 0.14

1.24 ± 0.61

HDL (mM)

1.39 ± 0.03

1.54 ± 0.06

1.43 ± 0.05

1.37 ± 0.04

1.60 ± 0.10

LDL (mM)

0.20 ± 0.01

0.20 ± 0.01

0.16 ± 0.01*

0.18 ± 0.02

0.22 ± 0.01

  1. TC total cholesterol; TG triacylglycerol; HDL high-density lipoprotein; LDL low-density lipoprotein. All parameters were measured at 8 weeks of age. Values are expressed as mean ± SEM
  2. *p < 0.05; ***p < 0.001 compared with the control group
  3. #p < 0.05; ##p < 0.01 compared with the F2/N-GDM group