Table 1 Overview of studies of age-related DNA methylation changes in multiple tissues
Species | Tissues (n) | CpGs (Platform) | Comparison of overlap at each level | Ref | ||
|---|---|---|---|---|---|---|
CpG | Functional genomic region | Gene | ||||
Humans | ||||||
Human | Buccal (96), liver (147), kidney (171) Th cells (214), brain (603), SC fat (648), monocytes (1202) | 428,279 (Illumina 450 k) | + | + | + | Current study |
Human | Cervix (3), bladder (5), intestine (5), kidney (6), head/neck (11), brain (12), pleura (18), placenta (19), lung (49), blood (85) | 1413 (GoldenGate) | – | – | – | [21] |
Human | Muscle (51), blood (71), brain (78), kidney (83) | 26,486 (27 k array) | + | – | – (GO terms) | [22] |
Human | Neuron (29), glia (29), MSCs (92), whole blood (656) | 429,789 (Illumina 450 k) | + | – | – | [13] |
Rodents | ||||||
Rat | Fat (3), liver (5–6) | 40,000 (HELP assay) | – | – | – | [45] |
Mouse | Liver (15), heart (15), lung (16), cortex (16) | 1,230,000 (RRBS) | + | – | – (GO terms) | [46] |