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Table 1 Overview of studies of age-related DNA methylation changes in multiple tissues

From: Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Species Tissues (n) CpGs (Platform) Comparison of overlap at each level Ref
CpG Functional genomic region Gene
Humans
Human Buccal (96), liver (147), kidney (171)
Th cells (214), brain (603), SC fat (648), monocytes (1202)
428,279
(Illumina 450 k)
+ + + Current study
Human Cervix (3), bladder (5), intestine (5), kidney (6), head/neck (11), brain (12), pleura (18), placenta (19), lung (49), blood (85) 1413
(GoldenGate)
[21]
Human Muscle (51), blood (71), brain (78), kidney (83) 26,486
(27 k array)
+ – (GO terms) [22]
Human Neuron (29), glia (29), MSCs (92), whole blood (656) 429,789
(Illumina 450 k)
+ [13]
Rodents
Rat Fat (3), liver (5–6) 40,000
(HELP assay)
[45]
Mouse Liver (15), heart (15), lung (16), cortex (16) 1,230,000
(RRBS)
+ – (GO terms) [46]