Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms

Table 2 SIN3 interacts with a variety of binding partners to perform its biological function

Associated SIN3 isoform	Interacting protein	Function	Ref
SIN3A SIN3B	MAD-MAX	Transcription factors involved in cell proliferation and differentiation	[9, 37]
SIN3A SIN3B	IKAROS	Transcription factor involved in lymphocyte development	[70]
SIN3A SIN3B	FOXK1	Transcription factor involved in regulation of myogenic progenitors	[71]
SIN3A	NANOG	Transcription factor involved in maintaining pluripotency of ES cells	[45, 72]
SIN3A	FAM60A	Transcriptional regulator involved in TGF-β signaling	[28, 46]
SIN3A	MeCP2	Methyl-CpG binding protein	[51]
SIN3A	OGT	O-GlcNac transferase	[73]
SIN3A	TET1	Tet methylcytosine dioxygenase (involved in DNA demethylation)	[19]
SIN3A	BBX	Transcription factor important for cell cycle progression	[74]
SIN3A	SMRT	Hormone-sensitive transcriptional corepressor	[56]
SIN3A	BRG1, hBRM	ATPases involved in chromatin remodeling	[57]
SIN3B	EMSY	Transcriptional corepressor, BRCA2 binding protein	[75]
SIN3B	Na_v1.2, Na_v1.6	Voltage-gated sodium channels in neurons	[76]

Representative examples from the SIN3 interactome that contribute to the functional flexibility of SIN3

ISSN: 1756-8935