Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms

Epigenetics & Chromatin

Table 1 SIN3 plays a dual role in transcription regulation

Organism	Isoform studied	Transcriptome analysis		Genome-wide binding		GO categories	Ref
Organism	Isoform studied	Genes activated	Genes repressed	Genes activated	Genes repressed	GO categories	Ref
S. c.	na	269	173	ns		Cell cycle regulation, carbon metabolite, carbohydrate utilization, and transport	[12]^#
S. c.	na	ns		100		Cell cycle regulation	[69]*
D. m.	SIN3 220	35	364	ns		Cell cycle regulation, signal transduction, transcription, metabolism	[13]^#
	SIN3 187	605	669	338	282	Both: cell cycle regulation, intracellular transport, metabolism, SIN3 187: development, apoptosis	[20]^##**
	SIN3 220	349	263	162	243		[20]^##**
M. m.	SIN3A	331	977	ns		Cell cycle regulation, DNA repair, energy generation	[14]^#
	SIN3A	ns		707		Cell cycle regulation, metabolism, transcription	[53] *
	SIN3B	ns		686		Cell cycle regulation, metabolism, transcription	[53] *
	SIN3A	ns		1491		Both: cell cycle regulation, RNA processing, DNA replication/repair SIN3B redox, protein transport, protein catabolism	[61] **
	SIN3B	ns		4993			[61] **
H. s.	SIN3A	2587	2662	1120	1586	Cellular process, development	[19]^#**

Genome-wide expression and binding analyses for SIN3 in different organisms. Enriched GO categories are listed to indicate biological functions of regulated genes
Na, not applicable; ns not studied. S.c., Saccharomyces cerevisiae; D.m., Drosophila melanogaster; M.m., Mus musculus; H.s., Homo sapiens
Asterisk and hashtag symbols indicate the experimental approach used in specific studies to generate expression and binding data
^#Microarray, ^##RNA-seq, *ChIP-chip, **ChIP-seq

ISSN: 1756-8935