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Table 1 SIN3 plays a dual role in transcription regulation

From: Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms

Organism Isoform studied Transcriptome analysis Genome-wide binding GO categories Ref
Genes activated Genes repressed Genes activated Genes repressed
S. c. na 269 173 ns Cell cycle regulation, carbon metabolite, carbohydrate utilization, and transport [12]#
na ns 100 Cell cycle regulation [69]*
D. m. SIN3 220 35 364 ns Cell cycle regulation, signal transduction, transcription, metabolism [13]#
SIN3 187 605 669 338 282 Both: cell cycle regulation, intracellular transport, metabolism, SIN3 187: development, apoptosis [20]##**
SIN3 220 349 263 162 243
M. m. SIN3A 331 977 ns Cell cycle regulation, DNA repair, energy generation [14]#
SIN3A ns 707 Cell cycle regulation, metabolism, transcription [53] *
SIN3B 686
SIN3A ns 1491 Both: cell cycle regulation, RNA processing, DNA replication/repair
SIN3B redox, protein transport, protein catabolism
[61] **
SIN3B 4993
H. s. SIN3A 2587 2662 1120 1586 Cellular process, development [19]#**
  1. Genome-wide expression and binding analyses for SIN3 in different organisms. Enriched GO categories are listed to indicate biological functions of regulated genes
  2. Na, not applicable; ns not studied. S.c., Saccharomyces cerevisiae; D.m., Drosophila melanogaster; M.m., Mus musculus; H.s., Homo sapiens
  3. Asterisk and hashtag symbols indicate the experimental approach used in specific studies to generate expression and binding data
  4. #Microarray, ##RNA-seq, *ChIP-chip, **ChIP-seq