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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-AHCP−3 Deposition and De Novo Centromere Establishment in Caenorhabditis elegans Artificial Chromosomes

Fig. 6

Summary and model of the effects of HDA-1-tethering and transcription on de novo centromere establishment. a Summary of the levels of H3K9 and H4 acetylations, RNA polymerase II serine 5 phosphorylation, and CENP-AHCP−3 in first-generation ACs at progressing embryo stages, propagated ACs and endogenous chromosomes in GFP::LacI- or GFP::LacI::HDA-1-tethering strains, and in GFP::LacI-tethering strain with alpha-amanitin treatment. b Schematic model of the proposed mechanism of histone acetylations and transcription in facilitating initial CENP-AHCP−3 incorporation into newly formed ACs, and supporting de novo centromere formation

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Epigenetics & Chromatin

ISSN: 1756-8935