Fig. 3
From: The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally
Genomic effects of Sus1 depletion on changes in mRNA half-lives. a Box-and-whisker plot of the changes in mRNA stability half-lives (HL) in sus1Δ mutant (dark grey) and the wild-type strain (light grey). All comparisons show a statistically significant HL increase of sus1Δ in relation to wild-type strains (Wilcoxon signed-rank test p value < 10−5). Note that SAGA- and TFIID-dominated genes have similar average increase in HLs (3.3- vs. 4.73-fold) but that ribosomal protein-coding genes (RP) are much more increased in HLs (7.7-fold) than environmental stress response activated (ESR-up) genes (2.75-fold). b Box-and-whisker plot of the changes in TR in the sus1Δ mutant (dark grey) and the wild-type strain (light grey). All comparisons show a statistically significant TR decrease of sus1Δ in relation to wild-type strains (Wilcoxon signed-rank test p value < 10−5). Note that the decrease in RP genes is much higher (19.4-fold) than in SAGA (5.5-fold), TFIID (7.1-fold) or ESR-up (4.4-fold) genes. c Plot of the fold change in HL in the sus1Δ mutant against the TR level of each gene in the WT strain. Note that both axes are in log2 scales of arbitrary units. Pearson R of the cloud to a linear fitting is shown