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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Genome-wide analysis of gene regulation mechanisms during Drosophila spermatogenesis

Fig. 3

Second layer of regulation in the gene activation cascade in spermatocytes. a Can peaks are present in the promoters of meiosis arrest genes topi, achi, and vis. Dotted lines designate the values corresponding to FDR = 0.05. b The effects of bam, can, and comr mutation on expression of these genes. Topi, achi, and vis are inactive in spermatogonia (bam), yet they become activated in spermatocytes. Despite identical cell composition in the testes of can and comr mutants, the genes topi, achi, and vis show much weaker expression in can mutants (asterisk designate P < 0.003). As a control, the data for Actin 42A gene are shown to illustrate that these mutations do not influence its expression

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