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Table 1 Predicted destabilization of the nucleosome, ∆∆G, due to histone acetylation compared to available experimental values as quantitative validation of the model [41, 43]

From: Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core

Acetylated group Experimental ΔΔG (kcal/mol) Predicted ΔΔG (kcal/mol)
H3K56 2.0 ± 0.6 2.3 ± 0.4
H3K115 0.4 ± 0.2 0.2 ± 0.01
H3K122 0.2 ± 0.2 0.3 ± 0.01
  1. The experimental uncertainty is discussed in the Additional file 1; errors in the predicted values are discussed in “Methods” section