Skip to main content

Table 1 Predicted destabilization of the nucleosome, ∆∆G, due to histone acetylation compared to available experimental values as quantitative validation of the model [41, 43]

From: Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core

Acetylated group

Experimental ΔΔG (kcal/mol)

Predicted ΔΔG (kcal/mol)

H3K56

2.0 ± 0.6

2.3 ± 0.4

H3K115

0.4 ± 0.2

0.2 ± 0.01

H3K122

0.2 ± 0.2

0.3 ± 0.01

  1. The experimental uncertainty is discussed in the Additional file 1; errors in the predicted values are discussed in “Methods” section
Back to article page

Epigenetics & Chromatin

ISSN: 1756-8935