Fig. 5

Histone sequences with all lysine residues annotated with experimentally known PTMs and color coded by our predicted effect on the DNA accessibility as in Figs. 4 and 5. Regions within the bold square brackets [] are considered part of the globular core, which is the focus of this work. Underlined residues denote mutations relative to the human variant of the histone. The ‘+’ in H2A refers to a missing residue relative to the human variant of H2A. Note that in the nucleosome crystal structure used here (PDB ID 1KX5) H4 is the only human histone variant; H2A and H2B are from xenopus and H3 is a bovine variant