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Fig. 1. | Epigenetics & Chromatin

Fig. 1.

From: Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core

Fig. 1.

The six conformational states used in the thermodynamic model of DNA accessibility in the nucleosome. The states differ by the degree of DNA accessibility and histone core composition. The DNA is completely inaccessible in the canonical nucleosome (W, wrapped). In each of the three partially wrapped conformations (P1, P3, P3) 20 bp are accessible. In the tetrasome (T), a total of 69 bp are accessible [62]. Each conformational state can also carry a post-translational modification (PTM) resulting in a total of twelve distinct energy states considered

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Epigenetics & Chromatin

ISSN: 1756-8935