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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells

Fig. 5

Impact of DNMTs and TET proteins on KAP1-mediated TE regulation. a Principal component analysis of TEs expression on data from wild-type, DNMT TKO and TET TKO mESCs control or Kap1 knockdown, obtained by RNA-seq. Data are from three (for WT and DNMT TKO samples) and two (for TET TKO samples) independent RNA-seq experiments. b, c, e and f Graphic representation of logged normalized counts across samples obtained by RNA-seq for TEs grouped in patterns P1 to P4. Families enriched for each pattern are depicted on the right with the p value from the hypergeometric test defining how significant over-representation is for each (blue heatmap), the percentage of KAP1-bound elements in the family (green heatmap) and the fold change of 5hmC upon Kap1 knockdown (red heatmap). d Scatter plot of the gene expression fold change between Kap1 knockdown and control samples for wild-type and TET TKO cells. Mid 2-cell genes are highlighted in green, Dux transcript in red

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Epigenetics & Chromatin

ISSN: 1756-8935