Fig. 3

Lower correlations among the expression levels of 7 DNA methylation-related enzymes in human cancer tissues. a Heat map of the correlations of gene expression levels among 7 DNA methylation-related enzymes in 12 normal tissues (upper triangle) and the corresponding tumor tissues (lower triangle). LGG: brain lower-grade glioma; BRCA: breast invasive carcinoma; COAD: colon adenocarcinoma; ESCA: esophageal carcinoma; KIRC: kidney renal clear cell carcinoma; KIRP: kidney renal papillary cell carcinoma; LIHC: liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; PAAD: pancreatic adenocarcinoma; STAD: stomach adenocarcinoma; THCA: thyroid carcinoma; and UCEC: uterine corpus endometrial carcinoma. b Bar plot of the correlations among the expression levels of 21 gene pairs in normal and tumor tissues. *p < 0.05, **p < 0.01 and ***p < 0.001 by paired t test. c Cluster analysis based on the correlation levels of 21 gene pairs (x-axis) in 12 normal and tumor tissues (y-axis). Each square represents one out of 21 correlations in one normal or tumor tissue. d The connectivity map of 7 genes; the edge thinness and color represent the number of tissue types in which the correlation of the gene pair is higher in the normal tissue than in the tumor tissue