Fig. 1

Significant positive correlations among DNA methylation-related enzymes in 5 normal mouse tissues. a Schematic overview of the cyclic distribution of different forms of cytosine. After establishment by DNA methyltransferases (DNMTs), 5mC undergoes stepwise oxidation to 5hmC, 5fC and 5caC via the TET family enzymes (TETs), and 5fC and 5caC can be then replaced with unmodified cytosine by TDG in conjunction with the base excision repair pathway (not shown). b The value of the correlations between each DNA methylation-related enzyme pair in 5 normal mouse tissues is shown. The balls in different colors represent the Pearson correlation coefficients among the expression levels of 7 DNA methylation-related enzymes (one ball refers to one enzyme pair). The DNA methylation-related enzyme pairs are indicated below. In this study, when the correlation coefficient r was higher than 0.3 (dotted line), the correlation was significantly positive (p < 0.05). The detailed Pearson correlation coefficient values and their corresponding p values are shown in Additional file 2: Table S1. c The correlations between DNMT3A and TET2 in 5 normal mouse tissues are shown. For each tissue type, the normalized mRNA levels of TET2 (y-axis) versus the normalized mRNA levels of DNMT3A (x-axis) are shown (one ball refers to one sample). The Pearson correlation coefficient and p value are also shown