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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: A screening system to identify transcription factors that induce binding site-directed DNA demethylation

Fig. 6

Family DNA-demethylating TFs share demethylation targets. a Position weight matrix-based sequence logos of TFBMs for RUNX1 (top left), RUNX3 (bottom left), CEBPA (top right), and CEBPB (bottom right). The height of each letter represents the probability of TF appearance at binding sites. b Overlap of demethylated CpGs between RUNX1-overexpressing (red) and RUNX3-overexpressing (blue) cells and between CEBPA-overexpressing (red) and CEBPB-overexpressing (blue) cells. The number of overlapping CpGs is shown at the intersection of each circle. The total number of demethylated CpGs is depicted as a particular circle size and is shown above the circles

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