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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: A screening system to identify transcription factors that induce binding site-directed DNA demethylation

Fig. 5

Local effect of TF-mediated DNA demethylation. a DNA methylation patterns of demethylated regions, selected from methylation array results, were analyzed by bisulfite-PCR sequencing. Each circle represents a cytosine of CpG. Black and white circles indicate methylated and unmethylated cytosine, respectively. Horizontal lines represent the sequencing result of each sub-clone. Arrows represent the position of demethylated CpGs identified by methylation array analysis (*p < 0.05; **p < 0.01; Fisher’s exact test). b Gaussian distribution model fitting of enrichment score peaks. X-axis shows the distance from demethylated CpGs. Y-axis represents the enrichment score (left) and probability of the Gaussian distribution model (right). Gray plots are enrichment scores from Figs. 1c and 2b, and red dotted plots are fitted Gaussian distributions

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