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Fig. 8 | Epigenetics & Chromatin

Fig. 8

From: Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits

Fig. 8

Hierarchical model of functional interactions between BRG1 and BRM. a Interactions in layer 1 are primarily between SWI/SNF complexes, excluding secondary complexes from the locus. Upon loss of one of the ATPase subunits, the remaining complex association with the locus, and transcriptional output is controlled by the identity and action of the secondary complex. Interactions with the remaining SWI/SNF complex supplant SWI/SNF occupancy (b, d) or retain it c). If the remaining complex is evicted, the transcriptional output is controlled by the whether the new complex is repressive (b) or activating (c, d)

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