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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning

Fig. 6

Genes most transcriptionally affected by dst1∆ exhibit both occupancy and fuzziness nucleosomal alterations. a Comparison between the nTR of the wild-type and dst1∆ cells across the genome. The boxplot compares the median of the two nTR distributions shown in Additional file 10 A. The two distributions significantly differ according to the Wilcoxon–Mann–Whitney U-test. b The scatter plot of the dst1∆/wt nTR ratio versus the wt nTR. c Average nucleosomal profile in the wild-type and dst1∆ cells of those genes whose GRO signal went below one half in dst1∆, aligned to the TSS. d, e Distribution of the gene body (d) and promoter (e) nucleosomal fuzziness scores of those genes whose GRO signals went below one half in dst1∆. f Comparison between the dst1∆/wt nTR ratios of the TATA and TATA-like genes. The two distributions significantly differ according to the Wilcoxon–Mann–Whitney U-test. g, h Bio-GRO signals of TATA-like (g) and TATA genes (h) in the wild type and dst1∆. After classification, genes were aligned to their TSS, as in Fig. 1a. The corresponding nucleosomal metagenes are shown as a reference

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