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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Phylogenetic analysis of the core histone doublet and DNA topo II genes of Marseilleviridae: evidence of proto-eukaryotic provenance

Fig. 4

MV DNA topoisomerase II gene is unassignable to any one eukaryotic lineage. The DNA topoisomerase II protein encoded by MV genomes possesses additional domains not seen in the Euryarchaeota DNA gyrase subunit. To determine whether the MV DNA topoisomerase II was derived from a particular eukaryotic lineage, a Bayesian phylogenetic analysis (1 M generations, 25% burn-in of sampling mixed amino acid models, with WAG having complete posterior probability and avg. st. dev. of split freq. = 0.00047) was conducted using top eukaryotic hits from a query using the Lausannevirus DNA topoisomerase II sequence. This identified fungal sequences as the top hits. The top fungal hits (labeled by % identity and % query coverage from the BLASTP query) and the top non-fungal hits were included in the analysis without the archaeal sequences. The results of this analysis are consistent with a model in which the MV DNA topoisomerase II gene was derived from an unknown branch of the stem-eukaryotic (non-eukaryotic) lineage

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