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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Phylogenetic analysis of the core histone doublet and DNA topo II genes of Marseilleviridae: evidence of proto-eukaryotic provenance

Fig. 3

All MV genomes encode a basal eukaryotic DNA topoisomerase II protein. The presence of eukaryote-like nucleosomal chromosomes in MV is likely to require adaptations in the complexes operating at viral DNA replication forks. Analysis of MV genomes shows that the most conserved gene across MV and Eukarya is the gene encoding the large DNA topoisomerase II enzyme, which functions at the replisome. Together, phylogenetic analyses of the MV core histones and the MV DNA topoisomerase II show that these MV genes do not group within eukaryotes or Archaea. a Phylogenetic analysis by maximum likelihood on an alignment including all 529 columns with > 90% data from all taxa and the JTT substitution matrix [57]. Support values are from 500 bootstrap replicate data sets from 529 alignment columns that remained after a threshold cutoff of 90% data was applied. Only percent bootstrap replicate values > 60% are shown. b Phylogenetic analysis by Bayesian MCMC using the same alignment as in (a). 2,000,000 generations of parallel runs with final average standard deviation of split frequencies = 0.0129 with 25% burn-in generations after sampling mixed amino acid models. Final generations sampled the Wag substitution model

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