TY - JOUR AU - Denisenko, Elena AU - Guler, Reto AU - Mhlanga, Musa M. AU - Suzuki, Harukazu AU - Brombacher, Frank AU - Schmeier, Sebastian PY - 2017 DA - 2017/10/23 TI - Genome-wide profiling of transcribed enhancers during macrophage activation JO - Epigenetics & Chromatin SP - 50 VL - 10 IS - 1 AB - Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of which M(IFN-γ) and M(IL-4/IL-13) are well known for their opposing pro- and anti-inflammatory roles. Enhancers have emerged as regulatory DNA elements crucial for transcriptional activation of gene expression. SN - 1756-8935 UR - https://doi.org/10.1186/s13072-017-0158-9 DO - 10.1186/s13072-017-0158-9 ID - Denisenko2017 ER -