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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: H2A O-GlcNAcylation at serine 40 functions genomic protection in association with acetylated H2AZ or γH2AX

Fig. 1

Cell cycle-independent H2AS40Gc production. a Three-dimensional reconstruction map of core histones. Arrowheads indicate residue 40 of H2A. b Sequence diversity of L1 loop region in H2A. c List of canonical H2As in mice. This list is based on Refseq database (mouse mm9). d Left, expression level of H2A-coding genes in synchronized mESCs. Values are expressed as relative to that of thymidine-treated (14 h) mESCs, which is set as 1. Right, expression level of mRNA for H2A-coding genes using cDNA synthesized using oligo(dT) primer or random hexamer (RH) in non-synchronized mESCs. Values are normalized by Actb expression. e H2AS40Gc level in synchronized mESCs. Cyclin E and phosphorylated H3S10 (H3S10Phos) were used to determine cell cycle phases. Actb was used as the internal control. f Summary of canonical and variant H2A gene expression through cell cycle

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Epigenetics & Chromatin

ISSN: 1756-8935