NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosage-compensated monosomic chromosome that confers resistance to fungal toxins

Table 1 Candida albicans strains used in this study

Strain	Genotype	Source
BWP17	ura3-∆::imm434/ura3-∆::imm434, arg4-∆::hisG/arg-∆::hisG, his1-∆::hisG/his1-∆::hisG	Tag-Module collection
Esa1	Same as BWP17, but esa1-∆/ESA1	Same as above
DAY286	Same as BWP17, but ura3-∆::imm434/ura3-∆::imm434, ARG4::URA3::arg4-∆::hisG/arg-∆::hisG, his1-∆::hisG/his1-∆::hisG	FGSC^a
DAY286-1	Same as DAY286, but Ch5 monosomy	This study
Nbn1	Same as DAY286, but nbn1-∆/nbn1-∆	FGSC
Nbn1-1	Same as Nbn1, but Ch5 monosomy	This study
Nbn1-2	Same as Nbn1, but Ch5 monosomy	This study
Nbn1-3	Same as Nbn1, but Ch5 monosomy	This study
Eaf3	Same as DAY286, but eaf3-∆/eaf3-∆	FGSC
Eaf3-1	Same as Eaf3, but Ch5 monosomy	This study
3153A	Laboratory strain, normal diploid	[8, 27]
Sor125(55)
a.k.a. Sor55	Same as 3153A, but Ch5 monosomy, MTLα, and Ch4/7b trisomy^b	[8, 27]

^aFungal Genomic Strains Center
^bBoth Sor125(55) and its parental strain, 3153A, harbor two hybrid chromosomes resulting from a reciprocal exchange between a Ch4 and a Ch7 of the reference strain SC5314 [8], which we term Ch4/7a and Ch4/7b. In Sor125(55), Ch4/7b is duplicated; therefore, genes on this hybrid chromosome, together with the corresponding portions of the intact Ch4 and Ch7, have a copy number of three [8]

ISSN: 1756-8935